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Paracetamol alters empathy scores in healthy and headache subjects: Functional MRI correlates
(Elsevier Science Ltd., 2020)Introduction: Although previous evidence suggest that paracetamol decreases psychological reactivity in healthy subjects, there is still no confirmed correlation between the empathy scores and brain activity in healthy and ... -
Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice
(Elsevier Sciences Bv, 2017)Apart from its potent antioxidant property, recent studies have revealed that melatonin promotes PI3K/Akt phosphorylation following focal cerebral ischemia (FCI) in mice. However, it is not clear (i) whether increased ... -
Patient-specific induced pluripotent stem cells for cardiac disease modeling
(Walter de Gruyter GMBH, 2019)Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) via induction of pluripotency genes is one of the most influential scientific breakthroughs during the last decade. Behind this breakthrough ... -
Phosphodiesterase 10A deactivation induces long-term neurological recovery, peri-infarct remodeling and pyramidal tract plasticity after transient focal cerebral ischemia in mice
(Academic Press Inc., 2022)The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are involved in several neuronal functions. High PDE10A ... -
Phosphodiesterase 10A is a critical target for neuroprotection in a mouse model of ischemic stroke
(Springer, 2022)Phosphodiesterase 10A (PDE10A) hydrolyzes adenosine 3 ',5 '-cyclic monophosphate (cAMP) and guanosine 3 ',5 '-cyclic monophosphate (cGMP). It is highly expressed in the striatum. Recent evidence implied that PDE10A may be ... -
Phosphorylation of PI3K/Akt at Thr308, but not phosphorylation of MAPK kinase, mediates lithium-induced neuroprotection against cerebral ischemia in mice
(Academic Press Inc., 2022)Lithium, in addition to its effect on acute and long-term bipolar disorder, is involved in neuroprotection after ischemic stroke. Yet, its mechanism of action is still poorly understood, which was only limited to its ... -
Plasma leptin, nesfatin 1, NPY, and zinc levels in obese and metabolic syndrome children
(Pera Yayincilik Hizmetleri, 2023)Objective: The aim of this study is to investigate the relationship between leptin, nesfatin 1 and NPY hormones and zinc in boys and girls diagnosed with metabolic syndrome and obesity. Methods: This study included a ... -
The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20
(Nature Publishing Group, 2019)TNF alpha is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNF alpha exerts ... -
Post-stroke transplantation of adult subventricular zone derived neural progenitor cells - A comprehensive analysis of cell delivery routes and their underlying mechanisms
(Academic Press, 2015)With neuroprotective approaches having failed until recently, current focus on experimental stroke research has switched towards manipulation of post-ischemic neuroregeneration. Transplantation of subventricular zone (SVZ) ... -
Potential diagnostic value of abnormal pyroptosis genes expression in myelodysplastic syndromes (MDS): A primary observational cohort study
(2024)Background: Myelodysplastic syndromes (MDS) are determined by ineffective hematopoiesis and bone marrow cytological dysplasia with somatic gene mutations and chromosomal abnormalities. Accumulating evidence has revealed ... -
Potential of novel methyl jasmonate analogs as anticancer agents to metabolically target HK-2 activity in glioblastoma cells
(Frontiers Media S.A., 2022)Change in the energy metabolism of cancer cells, which display significant differences compared to normal cells, is a rising phenomenon in developing new therapeutic approaches against cancers. One of the metabolic enzymes, ... -
Power spectral density and coherence analysis of eye disease with and without visual hallucination
(Elsevier Ireland Ltd, 2021)Objectives: Charles Bonnet Syndrome (CBS) is a rare clinical condition which has been defined as complex visual hallucinations (CVH) due to visual loss. This study investigated differences in the EEG power spectral density ... -
Preclinical molecular signatures of spinal cord functional restoration: Optimizing the metamorphic axolotl (ambystoma mexicanum) model in regenerative medicine
(Mary Ann Liebert, 2020)Regenerative medicine offers hope for patients with diseases of the central and peripheral nervous system. Urodele amphibians such as axolotl display an exceptional regenerative capacity and are considered as essential ... -
Predicting the effects of repetitive transcranial magnetic stimulation on cognitive functions in patients with alzheimer's disease by automated EEG analysis
(Frontiers Media SA, 2022)Alzheimer's disease (AD) is a progressive, neurodegenerative brain disorder that generally affects the elderly. Today, after the limited benefit of the pharmacological treatment strategies, numerous noninvasive brain ... -
Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
(Nature Publishing Group, 2019)Although clinically apparent metastasis is associated with late stages of cancer development, micro-metastatic dissemination may be an early event. However, the fate of these early disseminated tumor cells (DTC) remains ... -
Protective effect of lutein/zeaxanthin isomers in traumatic brain injury in mice
(Springer, 2021)Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic brain injury (TBI). In an earlier study, we reported that lutein/zeaxanthin isomers (L/Zi) exert ... -
Protein kinaz C aktivatörü PMA’nın TRPV1 kanalları üzerindeki etkileri
(Hacettepe Üniversitesi, 2015)TRP alt ailesinin bir üyesi olarak bilinen TRPV1 kanalları non-selektif katyon kanallarıdır. Bu kanalların en fazla bulunduğu dokular; arka kök gangliyon nöronları, vagal nöronlar ve trigeminal gangliyon nöronlarıdır. TRPV1 ... -
Proteome data to explore the axolotl limb regeneration capacity at neotenic and metamorphic stages
(Elsevier, 2020)The presented data article reports protein expression profiles during a time course of limb regeneration in the highly regenerative neotenic and regeneration-deficient metamorphic axolotl (Ambystoma mexicanum). A protein ... -
A proteomic analysis for profiling NeuroD2 related changes in N2A neuroblastoma cell line
(Inönü University Faculty of Medicine, 2023)Aim: NeuroD2 transcription factor is a key regulator of neurogenin-NeuroD signaling network and induces neuronal development, differentiation, neurogenesis and calcium de- pendent signaling. NeuroD2 regulates expression ... -
Proteomic analysis of kidney preservation solutions prior to renal transplantation
(Public Library Science, 2016)One of the main issues in kidney transplantation is the optimal functional preservation of the organ until its transplantation into the appropriate recipient. Despite intensive efforts, the functional preservation period ...
