Başlık için Makale Koleksiyonu listeleme
Toplam kayıt 297, listelenen: 162-181
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Interaction of melatonin and Bmal1 in the regulation of PI3K/AKT pathway components and cellular survival
(Nature Publishing Group, 2019)The circadian rhythm is driven by a master clock within the suprachiasmatic nucleus which regulates the rhythmic secretion of melatonin. Bmal1 coordinates the rhythmic expression of transcriptome and regulates biological ... -
Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo
(Oxford University Press, 2017)Aims Fibrin deposition and absent endothelium characterize unhealed stents that are at heightened risk of stent thrombosis. Optical coherence tomography (OCT) is increasingly used for assessing stent tissue coverage as a ... -
Investigating the effects of glucose and lipid metabolism on neuronal structure using optical coherence tomography in treatment-resistant schizophrenia
(Kare Publishing, 2023)Objective:The effects of metabolic changes on neural structures in the later stages of schizophrenia remain unknown. Alterations in glucose and lipid metabolism could impact disease progression. This study aims to investigate ... -
Investigation of antioxidant and cytotoxic activities of Opuntia ficus-indica (L.) Mill. fruit extract
(Istanbul University, 2019)Opuntia ficus-indica fruits are claimed to possess several health-beneficial properties. This study was carried out to determine the phytochemicals as well as to compare antioxidant activity and cell viability of the ... -
The investigation of inflammation in drug-naive first-episode mania by measuring ferritin, peripheral inflammatory markers, and their ratios
(Istanbul University, 2024)Objective: Bipolar disorder (BD) is a complex psychiatric disorder with a multifactorial etiology involving both genetic and environmental factors. Increased inflammatory parameters have been shown in previous studies in ... -
Investigation of the effect of adalimumab on experimental brain injury in mice
(2019)Aim: We aimed to investigate the neuroprotective role of adalimumab based on the hypothesis that "TNF-alpha inhibitor adalimumab may affect inflammationrelated neuronal injury due to its anti-inflammatory effect". Methods: ... -
Is there a relationship between microvascular complications and the severity of type 2 diabetes mellitus?
(Erciyes University Faculty Of Medicine, 2020)Objective: The aim of this study was to determine the relationship between microvascular Type 2 diabetes mellitus (T2DM) complications and the severity and duration of diabetes in the light of sociodemographic and lifestyle ... -
Ischemic post-conditioning induces post-stroke neuroprotection via Hsp70-mediated proteasome inhibition and facilitates neural progenitor cell transplantation
(Humana Press Inc, 2017)In view of the failure of pharmacological therapies, alternative strategies promoting post-stroke brain repair are needed. Post-conditioning is a potentially promising therapeutic strategy, which induces acute neuroprotection ... -
Kurumda ve kendi evinde yaşayan bir grup yaşlı bireyin beslenme durumlarının değerlendirilmesi
(2020)Yaşlı nüfusun birçok ülkede olduğu gibi ülkemizde de hızla arttığı bilinmektedir. Yaşlılık döneminde, sağlığın iyileştirilmesi ve geliştirilmesinde, yaşam süresinin ve kalitesinin artırılmasında yeterli ve dengeli beslenme ... -
Left lateral parietal rTMS improves cognition and modulates resting brain connectivity in patients with Alzheimer's disease: Possible role of BDNF and oxidative stress
(Academic Press Inc., 2021)Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation technique which is increasingly used for cognitive impairment in Alzheimer?s Disease (AD). Although rTMS has been shown to modify ... -
Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract plasticity by regulating axonal growth inhibitors and guidance proteins
(Academic Press Inc Elsevier Science, 2020)Owing to its potent longterm neuroprotective and neurorestorative properties, glial cell line-derived neurotrophic factor (GDNF) is currently studied in neurodegenerative disease clinical trials. However, little is known ... -
Leptin in sperm analysis can be a new indicator
(Elsevier GMBH, 2019)Purpose Radiotherapy, chemotherapy, various tumors and invasive surgery can result in ejaculatory dysfunction and testicular insufficiency. Sperm cryopreservation is the only method which can provide a baby for couples. ... -
Light transmittance and surface roughness of a feldspathic ceramic CAD-CAM material as a function of different surface treatments
(BioMed Central Ltd., 2016)Background: The aim of the present study was to determine the effect of different surface treatments on light transmission of aesthetic feldspathic ceramics used in CAD-CAM chairside restorations. Methods: Forty eight ... -
Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target
(American Society for Biochemistry and Molecular Biology Inc., 2021)Hexokinase (HK) catalyzes the first step in glucose metabolism, making it an exciting target for the inhibition of tumor initiation and progression due to their elevated glucose metabolism. The upregulation of hexokinase-2 ... -
Lithium modulates miR-1906 levels of mesenchymal stem cell-derived extracellular vesicles contributing to poststroke neuroprotection by toll-like receptor 4 regulation
(Wiley, 2021)Lithium is neuroprotective in preclinical stroke models. In addition to that, poststroke neuroregeneration is stimulated upon transplantation of mesenchymal stem cells (MSCs). Preconditioning of MSCs with lithium further ... -
Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long-distance axonal regeneration
(Frontiers Media S.A., 2022)Spinal cord injury (SCI) induces neurological deficits associated with long-term functional impairments. Since the current treatments remain ineffective, novel therapeutic options are needed. Besides its effect on bipolar ... -
Lithium-induced neuroprotection in stroke involves increased miR-124 expression, reduced RE1-silencing transcription factor abundance and decreased protein deubiquitination by GSK3 beta inhibition-independent pathways
(Sage Publication Inc., 2017)Lithium promotes acute poststroke neuronal survival, which includes mechanisms that are not limited to GSK3 inhibition. However, whether lithium induces long-term neuroprotection and enhanced brain remodeling is unclear. ... -
Longitudinal 16S rRNA data derived from limb regenerative tissue samples of axolotl ambystoma mexicanum
(Nature Publishing Group, 2019)The Mexican axolotl (Ambystoma mexicanum) is a critically endangered species and a fruitful amphibian model for regenerative biology. Despite growing body of research on the cellular and molecular biology of axolotl limb ... -
Low oxalobacter formigenes colonization is associated with reduced bone mineral density in urinary stone forming patients
(S. Karger AG, 2014)Introduction: Lower bone mineral density (BMD) and reduced Oxalobacter formigenes colonization are common findings in urolithiasis patients. But none of the studies conducted investigated the relationship between decreased ... -
Lower prepulse inhibition in clinical high-risk groups but not in familial risk groups for psychosis compared with healthy controls
(Wiley, 2020)Aim: Although the lower level of prepulse inhibition (PPI) of the startle response is well known in schizophrenia, the onset of this difference is not clear. The aim of the present study was to compare PPI in individuals ...
