dc.contributor.author | Akkaya, Hatice | |
dc.contributor.author | Kılıç, Ertuğrul | |
dc.contributor.author | Eyüboğlu Dinç, Siğnem | |
dc.contributor.author | Yılmaz, Bayram | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:57:25Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:57:25Z | |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | Akkaya, H., Kılıç, E., Eyüboğlu Dinç, S. ve Yılmaz, B. (2014). Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats. Journal of Biochemical and Molecular Toxicology, 28(8), 373-377. https://dx.doi.org/10.1002/jbt.21573 | en_US |
dc.identifier.issn | 1095-6670 | |
dc.identifier.issn | 1099-0461 | |
dc.identifier.uri | https://dx.doi.org/10.1002/jbt.21573 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2973 | |
dc.description | WOS: 000340532800004 | en_US |
dc.description | PubMed ID: 24863683 | en_US |
dc.description.abstract | Apart from its effect on the regulation of reproductive function, recent studies indicate that kisspeptin may play roles in the antioxidant defense system. The antioxidant defense system and oxidative stress contribute to the etiology and pathogenesis of neuronal cell death after brain injury. We have investigated the postacute effect of kisspeptin-10 on brain injury induced by L-methionine. DNA fragmentation, malondialdehyde (MDA), reduced glutathione levels, and superoxide dismutase (SOD) activities were analyzed. Our results showed that methionine treatment increases apoptotic cell death. Kisspeptin alone showed no side effect on apoptotic cell death. However, kisspeptin treatment reversed the proapoptotic effect of methionine associated with reduced MDA and increased glutathione levels. Furthermore, SOD activity was completely depleted in methionine-treated animals. In conclusion, our results revealed that delayed kisspeptin-10 treatment reduces neuronal cell death by activation of SOD activity. | en_US |
dc.description.sponsorship | Turkish Academy of Sciences (TUBA/GEBIP/EK) | en_US |
dc.description.sponsorship | Contract Grant Sponsor: Turkish Academy of Sciences (TUBA/GEBIP/EK). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Hyperhomocysteinemia | en_US |
dc.subject | Methionine | en_US |
dc.subject | Kisspeptin | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Oxidative Stress | en_US |
dc.title | Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Biochemical and Molecular Toxicology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-6494-8923 | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 373 | en_US |
dc.identifier.endpage | 377 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1002/jbt.21573 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q2 | en_US |