dc.contributor.author | Kürtüncü, Murat | |
dc.contributor.author | Kaya, Dilaver | |
dc.contributor.author | Zuliani, Luigi | |
dc.contributor.author | Erdağ, Ece | |
dc.contributor.author | İçöz, Sema | |
dc.contributor.author | Uğurel, Elif | |
dc.contributor.author | Çavuş, Filiz | |
dc.contributor.author | Ayşit, Neşe | |
dc.contributor.author | Birışık, Ömer | |
dc.contributor.author | Vincent, Angela | |
dc.contributor.author | Eraksoy, Mefkure | |
dc.contributor.author | Vural, Burçak | |
dc.contributor.author | Akman Demir, Gülşen | |
dc.contributor.author | Tüzün, Erdem | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:51:06Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T19:51:06Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | Kürtüncü, M., Kaya, D., Zuliani, L., Erdağ, E., İçöz, S., Uğurel, E. ... Tüzün, E. (2013). CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). Cephalalgia, 33(2), 123-129. https://dx.doi.org/10.1177/0333102412463494 | en_US |
dc.identifier.issn | 0333-1024 | |
dc.identifier.uri | https://dx.doi.org/10.1177/0333102412463494 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/2147 | |
dc.description | WOS: 000312550000006 | en_US |
dc.description | PubMed ID: 23111027 | en_US |
dc.description.abstract | Background: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. Aim and methods: To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA). Results: Although HaNDL sera did not yield antibodies to any of the well-characterized neuronal surface or synapse antigens, protein macroarray and ELISA studies showed high-titer antibodies to a subunit of the T-type voltage-gated calcium channel (VGCC), CACNA1H, in sera of two HaNDL patients. Conclusion: Our results support the notion that ion channel autoimmunity might at least partially contribute to HaNDL pathogenesis and occurrence of neurological symptoms. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sage Publications Ltd | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | HaNDL | en_US |
dc.subject | Headache | en_US |
dc.subject | CACNA1H | en_US |
dc.subject | Voltage-Gated Calcium Channel | en_US |
dc.subject | Autoantibody | en_US |
dc.title | CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL) | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Cephalalgia | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 123 | en_US |
dc.identifier.endpage | 129 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1177/0333102412463494 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |