Effects of pinealectomy and melatonin application on Serum Melatonin, Nesfatin-1 and ghrelin levels
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Erişim
info:eu-repo/semantics/openAccessAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/Tarih
2023Yazar
Sönmez, SaadetMenevşe, Esma
Baltacı, Saltuk Buğra
Ünal, Ömer
Moğulkoç, Rasim
Baltacı, Abdulkerim Kasım
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Sönmez, S., Menevşe, E., Baltacı, S. B., Ünal, Ö., Moğulkoç, R. ve Baltacı, A. K. (2023). Effects of pinealectomy and melatonin application on Serum Melatonin, Nesfatin-1 and ghrelin levels. European Journal of Therapeutics, 29(3), 526-533. https://dx.doi.org/10.58600/eurjther1747Özet
Objective: In this study, it was aimed to investigate the relationship between the pineal gland and ghrelin and nesfatin-1 hormones in rats.
Methods: A total of 36 male rats were used in the study, and the animals were divided into 4 groups. Group 1, Control; Group 2, Pinealectomy (Px); Group 3, Px+Melatonin; Group 4 Melatonin. After the end of the experimental applications, melatonin, ghrelin and nesfatin-1 levels (ELISA) were determined in the blood samples taken from the animals.
Results: While pinealectomy resulted in suppression of melatonin levels, melatonin supplementation led to a significant increase in blood melatonin levels (p<0.01). Melatonin supplementation suppressed ghrelin levels, while pinealectomy increased ghrelin levels (P<0.01). On the other hand, Nesfatin-1 levels, which increased with melatonin support, were significantly suppressed by pinealectomy (p<0.01).
Conclusion: The findings of the study draw attention to an important relationship between the endocrine activity of the pineal gland and the hormones ghrelin and nesfatin-1, which play a critical role in nutrition. Consequently, administration of melatonin inhibits ghrelin but increases nesfatin-1.
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European Journal of TherapeuticsCilt
29Sayı
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