The prognostic value of P53 index in predicting the recurrence of early low-risk endometrial cancer
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info:eu-repo/semantics/embargoedAccessTarih
2023Yazar
Çakır, İlkerGülseren, Varol
Aköz, Gamze
Şahin, Zekiye
Sever, Barış
Emiralioğlu Çakır, Zübeyde
Sancı, Muzaffer
Kuru, Oğuzhan
Özdemir, İsa Aykut
Güngördük, Kemal
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Çakır, İ., Gülseren, V., Aköz, G., Şahin, Z., Sever, B., Emiralioğlu Çakır, Z. ... Güngördük, K. (2023). The prognostic value of P53 index in predicting the recurrence of early low-risk endometrial cancer. Journal of Obstetrics and Gynaecology Research, 49(10), 2487-2493. https://dx.doi.org/10.1111/jog.15754Özet
Aim: We aimed to clarify the clinical value of P53 index in patients with early low-risk endometrial cancer (EC) and find an optimal cut-off value of P53 index for predicting the recurrence of these patients.Methods: The clinicopathological data of 157 patients with early low-risk EC (stage 1A with grade 1 or 2 endometrioid EC) were analyzed. The optimal cut-off value of the P53 index was calculated by the receiver operating characteristic curve analysis and Youden index. Cox regression model was used to evaluate the independent prognostic predictors of recurrence of EC. Then all patients were divided into two groups according to the optimal cut-off value of the P53 index. Differences of the clinicopathological parameters between the two groups were compared.Results: Multivariate analysis showed age PR (p = 0.020) and P53 (p = 0.001) were independent prognostic factors for the recurrence of EC. The value of P53 index was found to be the optimal cut-off point of 17.5% in estimating the recurrence of EC. The 5-year recurrence-free survival rates of patients in the low P53 index group (<17.5%) and the high P53 index group (=17.5%) were 94.6% and 65.4% (p < 0.001).Conclusion: It has been revealed that the P53 index is a prognostic factor for recurrence in early low-risk EC. The optimal cut-off value of P53 index may contribute to the postoperative individualized treatment options for early low-risk EC patients.
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Journal of Obstetrics and Gynaecology ResearchCilt
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