dc.contributor.author | Ölmez, Fatma | |
dc.contributor.author | Oğlak, Süleyman Cemil | |
dc.contributor.author | Akgöl, Sedat | |
dc.contributor.author | Ölmez, Ömer Fatih | |
dc.contributor.author | Bilici, Ahmet | |
dc.contributor.author | Akbayır, Özgür | |
dc.contributor.author | Gedik Özköse, Zeynep | |
dc.contributor.author | Can, Esra | |
dc.contributor.author | Ünal, Ömer | |
dc.contributor.author | Acar Şirinoğlu, Hicran | |
dc.date.accessioned | 2023-07-13T11:25:04Z | |
dc.date.available | 2023-07-13T11:25:04Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Ölmez, F., Oğlak, S. C., Akgöl, S., Ölmez, Ö. F., Bilici, A., Akbayır, Ö. ... Acar Şirinoğlu, H. (2023). Clinicopathological and survival characteristics of mismatch repair status and PD-1 expression in serous ovarian cancer. Journal of College of Physicians and Surgeons Pakistan (JCPSP), 33(6), 666-672. https://dx.doi.org/10.29271/jcpsp.2023.06.666 | en_US |
dc.identifier.issn | 1022-386X | |
dc.identifier.issn | 1681-7168 | |
dc.identifier.uri | https://dx.doi.org/10.29271/jcpsp.2023.06.666 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11193 | |
dc.description.abstract | Objective: To evaluate the clinicopathological characteristics of mismatch repair (MMR) deficiency and its clinical outcomes by performing immunohistochemistry (IHC) for MMR genes in the serous ovarian cancer (SOC) tumour sections.Study Design: A retrospective case-control study. Place and Duration of the Study: Gynecology Department of Kanuni Sultan Suleyman Training and Research Hospital, and Department of Medical Oncology of Medipol University, between March 2001 and January 2020. Methodology: IHC was carried out for MLH1, MSH2, MSH6, and PMS2 on full-section slides from 127 SOCs to evaluate the MMR status. MMR-negative and MMR-low groups together were defined as MMR deficient and called microsatellite instability-high (MSI-H). The MSI status and expression of programmed cell death-1 (PD-1) were compared in SOCs with different MMR statuses. Results: A significantly higher frequency of MMR-deficient SOCs was diagnosed at early stages compared with the patients in the MSS group (38.6% and 20.6%, respectively, p=0.022). The frequency of cases with PD-1 expression was significantly higher in the MSI-H group (76.2%) than in the MSS counterparts (58.8%, p=0.028). Patients in the MSI-H group had significantly longer DFS (25.6 months) and OS (not reached) than those in the MSS group (16 months and 48.9 months, p=0.039 and p=0.026, respectively).Conclusion: MSI-H SOCs were diagnosed at an earlier stage as compared to MMR proficient cases. The presence of PD-1 expres-sion was significantly higher in cases presenting MMR deficiency compared with MMR-proficient cases. MSI status was significantly associated with DFS and OS. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | College of Physicians and Surgeons Pakistan | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Serous Ovarian Cancer | en_US |
dc.subject | Microsatellite Instability | en_US |
dc.subject | Mismatch Repair Deficiency | en_US |
dc.title | Clinicopathological and survival characteristics of mismatch repair status and PD-1 expression in serous ovarian cancer | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of College of Physicians and Surgeons Pakistan (JCPSP) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-7934-7039 | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 666 | en_US |
dc.identifier.endpage | 672 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.29271/jcpsp.2023.06.666 | en_US |
dc.institutionauthor | Ölmez, Ömer Fatih | |
dc.institutionauthor | Bilici, Ahmet | |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.wos | 001011668000013 | en_US |
dc.identifier.scopus | 2-s2.0-85163906852 | en_US |
dc.identifier.pmid | 37300263 | en_US |
dc.identifier.scopusquality | Q3 | en_US |