Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds
Erişim
info:eu-repo/semantics/closedAccessTarih
2022Yazar
Tay, Naime FundaBerk, Barkın
Duran, Murat
Kayagil, İsmail
Yurttaş, Leyla
Biltekin Kaleli, Sevde Nur
Yamaç, Mustafa
Karaduman, Ayşe Betül
Demirayak, Şeref
Üst veri
Tüm öğe kaydını gösterKünye
Tay, N. F., Berk, B., Duran, M., Kayagil, İ., Yurttaş, L., Biltekin Kaleli, S. N. ... Demirayak, Ş. (2022). Synthesis, antimicrobial activity and modeling studies of thiazoles bearing pyridyl and triazolyl scaffolds. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 77(9-10), 429-446. https://doi.org/10.1515/znc-2022-0002Özet
In this study, novel 4-(5-((2/3/4-substituted benzyl)thio)-4-(4-substituted phenyl)-4H-1,2,4-triazol-3-yl)-2-(pyridin-3/4-yl)thiazoles were synthesized following a multi-step synthetic procedure. All the compounds were screened with a panel of gram positive/negative bacteria, yeasts, and molds for antimicrobial activity using the disc diffusion method. Then, the minimum inhibitor concentration (MIC) and the minimum bactericidal concentration (MBC) values of active compounds were determined against Micrococcus luteus, Bacillus cereus, Listeria monocytogenes, and Staphylococcus aureus using the broth microdilution technique. These compounds were also screened for their inhibitory activities against S. aureus DNA gyrase by supercoiling assay. Furthermore, the crystal structure of S. aureus DNA gyrase B ATPase was subjected to a docking experiment to identify the possible interactions between the most active ligand and the active site. Lastly, the in silico technique was performed to analyze and predict the drug-likeness, molecular and ADME properties of the synthesized molecules.