Yazar "Sipahi, Hande" için listeleme
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Anti-inflammatory, analgesic and in vivo-in vitro wound healing potential of the Phlomis rigida Labill. extract
Okur, Mehmet Evren; Karadağ, Ayşe Esra; Özhan, Yağmur; Sipahi, Hande; Ayla, Şule; Daylan, Benay; Kültür, Şükran; Demirci, Betül; Demirci, Fatih (Elsevier Ireland Ltd, 2021)Ethnopharmacological relevance: The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders. Methods: For the identification of the active fraction, the air ... -
Biocompatibility of biomimetic multilayered alginate-chitosan/beta-TCP scaffold for osteochondral tissue
Algul, Derya; Sipahi, Hande; Aydın, Ahmet; Kelleci, Feyza; Özdatlı, Şükran; Yener, Fatma Gülgün (Elsevier Science, 2015)Biomimetic three-layered monolithic scaffold (TLS) intended for treatment of osteochondral defects was fabricated by using freeze drying method. The multilayered material was prepared with chitosan (C) and alginate (A) ... -
Energy drink induced lipid peroxidation and oxidative damage in rat liver and brain when used alone or combined with alcohol
Reis, Rengin; Charehsaz, Mohammad; Sipahi, Hande; Doğan Ekici, Asiye Işın; Macit, Çağlar; Akkaya, Hatice; Aydın, Ahmet (Wiley, 2017)Energy drinks (ED) are containing large doses of metabolic stimulants and its use with ethanol has increased dramatically among young adults. In this study, we examined the effects of ED exposure either alone or in combination ... -
Evaluation of burn wound healing activity of novel fusidic acid loaded microemulsion based gel in male Wistar albino rats
Okur, Mehmet Evren; Ayla, Şule; Yozgatlı, Vildan; Aksu, Neşe Buket; Yoltaş, Ayşegül; Orak, Duygu; Sipahi, Hande; Üstündaǧ Okur, Neslihan (Elsevier, 2020)The objective of the present research was to examine the possible usage of microemulsion based gel for fusidic acid (FA) dermal application as burn wound treatment. During the preparation of microemulsion, ethyl oleate as ... -
In vitro antibacterial, antioxidant, anti-inflammatory and analgesic evaluation of Rosmarinus officinalis L. flower extract fractions
Karadağ, Ayşe Esra; Demirci, Betül; Çaşkurlu, Ayşegül; Demirci, Fatih; Okur, Mehmet Evren; Orak, Deborah; Sipahi, Hande; Başer, Kemal Hüznü Can (Elsevier, 2019)Rosmarinus officinalis L. (rosemary) is a common culinary spice and herbal drug, which is used for centuries all over the world. In this present study, apolar to polar fractions of R. officinalis flowers were evaluated for ... -
In vivo wound healing and in vitro anti-inflammatory activity evaluation of phlomis russeliana extract gel formulations
Okur, Mehmet Evren; Karadağ, Ayşe Esra; Üstündağ Okur, Neslihan; Özhan, Yağmur; Sipahi, Hande; Ayla, Şule; Daylan, Benay; Demirci, Betül; Demirci, Fatih (MDPI, 2020)The air-dried aerial parts of Phlomis russeliana (Sims) Lag. Ex Benth. was extracted by methanol and fractionated by n-hexane, dichloromethane, and ethyl acetate, respectively. The wound healing properties of P. russeliana ... -
New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test
Arpa, Muhammet Davut; Yoltaş, Ayşegül; Onay Tarlan, Ecehan; Şahin Şenyüz, Cemre; Sipahi, Hande; Aydın, Ahmet; Üstündağ Okur, Neslihan (Taylor and Francis Ltd., 2020)The objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent ... -
A novel approach in the treatment of osteoarthritis: In vitro and in vivo evaluation of Allium sativum microemulsion
Okur, Mehmet Evren; Kolbaşı, Bircan; Şahin, Mustafa; Karadağ, Ayşe Esra; Reis, Rengin; Çağlar, Emre Şefik; Kaplan, Arife Ahsen; Sipahi, Hande; Keskin, İlknur; Demiralp, Bahtiyar; Üstündağ Okur, Neslihan (Wiley, 2022)Osteoarthritis (OA) is the most prevalent kind of joint disease, affecting millions of individuals worldwide. Allium sativum L. was used as a therapeutic agent in the microemulsion system against osteoarthritis due to ... -
Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
Şahin, Zafer; Özhan, Yağmur; Sipahi, Hande; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Demirayak, Şeref (Walter de Gruyter GmbH, 2022)Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with alpha-hydroxy ... -
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition
Şahin, Zafer; Biltekin, Sevde Nur; Yurttaş, Leyla; Berk, Barkın; Özhan, Yağmur; Sipahi, Hande; Gao, Zhanguo; Jacobson, Kenneth A.; Demirayak, Şeref (Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well ... -
Novel microemulsion containing benzocaine and fusidic acid simultaneously: Formulation, characterization, and in vitro evaluation for wound healing
Arpa, Muhammet Davut; Çağlar, Emre Şefik; Güreşçi, Dilara; Sipahi, Hande; Üstündağ Okur, Neslihan (Springer Science and Business Media Deutschland GmbH, 2024)Modern drug carrier technologies, such as microemulsions with small droplet sizes and high surface areas, improve the ability of low water solubility active ingredients to permeate and localize. The goal of this study was ... -
Phytochemical and in vitro pharmacological evaluation of Phlomis Pungens
Okur, Mehmet Evren; Karadağ, Ayşe Esra; Reis, Rengin; Sipahi, Hande; Arslan, Rana; Demirci, Betül; Demirci, Fatih (Ankara University, 2022)Objective: This study aimed to investigate the in vitro wound healing, anti-inflammatory, antimicrobial and antioxidant activity of Phlomis pungens Willd. extract derived from the aerial parts. Material and Method: The ... -
Traditional herbal drugs against liver diseases – Experimented in vitro using HepG2 cells for induced steatosis
Karadağ, Ayşe Esra; Okur, Mehmet Evren; Özhan, Yağmur; Sipahi, Hande; Demirci, Fatih (Marmara University, 2023)Salvia fruticosa leaves, Malva sylvestris flowers, Taraxacum officinale aerial parts, Plantago ovata seeds, Tanacetum parthenium aerial parts, and Allium sativum bulbs are documented for traditional use against hepatic ... -
Wound healing effect of naringin gel in alloxan induced diabetic mice
Okur, Mehmet Evren; Şakul, Ayşe Arzu; Ayla, Şule; Karadağ, Ayşe Esra; Şahin Şenyüz, Cemre; Batur, Şebnem; Daylan, Benay; Özdemir, Ekrem Musa; Palabıyık-Yücelik, Sezin; Sipahi, Hande; Aydın, Ahmet (Ankara University Faculty of Pharmac, 2020)Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound. Material and ...