Browsing by Author "Sezer, Zehra"
Now showing items 1-3 of 3
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Gentisic acid exerts neuroprotective effects in neurotoxin-induced Parkinson's disease model in zebrafish: Cross-talk between pathways related with neurodegeneration in the gut-brain axis
Cansız, Derya; Ünal, İsmail; Sürmen, Mustafa Gani; Sürmen, Saime; Sezer, Zehra; Beler, Merih; Güzel, Elif; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (2024)Given that global prevalence of Parkinson's disease (PD) is expected to rise over the next few decades, understanding the mechanisms and causes of PD is critical. With emphasis on gut-brain axis, we sought to assess the ... -
Identification of molecular network of gut-brain axis associated with neuroprotective effects of PPAR delta-ligand erucic acid in rotenone-induced Parkinson's disease model in zebrafish
Ünal, İsmail; Cansız, Derya; Sürmen, Mustafa Gani; Sürmen, Saime; Sezer, Zehra; Beler, Merih; Üstündağ, Ünsal Veli; Güzel, Elif; Alturfan, Ahmet Ata; Emekli Alturfan, Ebru (Wiley, 2023)Disruption of the gut-brain axis in Parkinson's disease (PD) may lead to motor symptoms and PD pathogenesis. Recently, the neuroprotective potential of different PPAR delta-agonists has been shown. We aimed to reveal the ... -
Sodium-dependent glucose co-transporter-2 inhibitor empagliflozin exerts neuroprotective effects in rotenone-induced Parkinson's disease model in zebrafish; mechanism involving ketogenesis and autophagy
Ünal, İsmail; Cansız, Derya; Beler, Merih; Sezer, Zehra; Güzel, Elif; Emekli Alturfan, Ebru (Elsevier B.V., 2023)Sodium-dependent glucose co-transporter-2 (SGLT2) inhibitor empagliflozin (EMP), is the new class of oral hypoglycemic agent approved as a treatment for Type 2 diabetes. SGLT2 inhibitors may induce ketogenesis through ...