Yazar "Keskin, İlknur" için listeleme
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Hayvan çalışmalarında uygun model seçim kuralları ve etik durum
Altun, Ayşe; Keskin, İlknur (Sakarya Üniversitesi, 2020)Bilginin öğrenilmesi araştırmalar yapılarak elde edilebilmektedir. İnsan anatomisi, fizyolojisi, doku-organ sistemi üzerinde bilgi elde etmek herhangi bir canlıya zarar vermeden olmalıdır. İnsanlarla ilgili yapılan çalışmalar ... -
A histological atlas of the tissues and organs of neotenic and metamorphosed axolotl
Demircan, Turan; İlhan, Ayşe Elif; Aytürk, Nilüfer; Yıldırım, Berna; Öztürk, Gürkan; Keskin, İlknur (Elsevier GmbH, 2016)Axolotl (Ambystoma Mexicanum) has been emerging as a promising model in stem cell and regeneration researches due to its exceptional regenerative capacity. Although it represents lifelong lasting neoteny, induction to ... -
A histopathological evaluation of ovarian hyperstimulation syndrome on reproductive and vital organs and the role of the VEGF-PKA pathway in a mouse model
Karabulut, Seda; Korkmaz, Oya; Erdem Altun, Ceren; Keskin, İlknur (Karger, 2021)Ovarian hyperstimulation syndrome (OHSS) is one of the most common and iatrogenic complications of in vitro fertilization therapy, which is an exaggerated response to excess hormones resulting in the development of a large ... -
In 2D and 3D cell culture models, effects of endothelial cells on E-cadherin / β-catenin expression levels and spheroid sizes in ishikawa cells
Kalender, Mervenur; Bülbül, Muhammet Volkan; Kolbaşı, Bircan; Keskin, İlknur (Asian Pacific Organization for Cancer Prevention, 2022)Increasing evidence shows that three dimensional cell culture models better reflect the in vivo tumor microenvironment than two dimensional cell culture models. Co-culture models are ideal cell culture models for understanding ... -
Intracytoplasmic morphologically selected sperm injection, but for whom?
Karabulut, Seda; Aksünger, Özlem; Korkmaz, Oya; Eren Gözel, Hilal; Keskin, İlknur (Cambridge University Press, 2019)Intracytoplasmic sperm injection (ICSI) is performed in cases of infertility by injecting a motile and morphologically normal sperm cell under a routine ×400 magnification at which is hard to distinguish morphologically ... -
Ishikawa ve huvec hücreleri ile oluşturulmuş sferoid mono-kültür ve sferoid ko-kültür modellerinin morfolojik ve immünohistokimyasal (E-kaderin ve beta-katenin) olarak karşılaştırılması
Kalender, Semiha Mervenur (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Günümüzde giderek artan kanıtlar, üç boyutlu hücre kültürü modellerinin, iki boyutlu hücre kültürü modellerine göre in vivo tümör mikro ortamını daha iyi yansıttığını göstermektedir. Ko-kültür modelleri, hücreler ve in ... -
Juvenil dönemde yüksek fruktoz içerikli diyetle beslenmenin perilipin ekspresyonu üzerinden polikistik over sendromu gelişimi ile ilişkisi
Bedri, Nejda (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Polikistik over sendromu (PCOS) oluşumunda etkili olan çevresel faktörlerin başında beslenme yer almaktadır. PCOS ve yüksek fruktoz içerikli diyet birlikteliğini gösteren çalışmalar kısıtlı sayıdadır. Çalışmamızda juvenil ... -
Kronik stresin fare kan-testis bariyeri protein yapısı ve geçirgenliği üzerine etkisinin araştırılması
Kolbaşı, Bircan (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2019)Stres, dünya genelinde 21. yüzyılın salgın hastalığı olarak görülmektedir. Stres sonucunda oluşan depresyon, anksiyete ve intihara eğilim gibi semptomların teşhisi ve tedavisi özellikle Amerika Birleşik Devletleri gibi ... -
Leptin in sperm analysis can be a new indicator
Önel, Tuğçe; Ayla, Şule; Keskin, İlknur; Parlayan, Cüneyd; Yiğitbaşı, Türkan; Kolbaşı, Bircan; Varlı Yelke, Tuba; Şenel Ustabaş, Tuğba (Elsevier GMBH, 2019)Purpose Radiotherapy, chemotherapy, various tumors and invasive surgery can result in ejaculatory dysfunction and testicular insufficiency. Sperm cryopreservation is the only method which can provide a baby for couples. ... -
Male infertility, azoozpermia and cryptozoospermia incidence among three infertility clinics in Turkey
Karabulut, Seda; Keskin, İlknur; Kutlu, Pelin; Delikara, Nuri; Atvar, Özhan; Öztürk, Metin İshak (AVES İbrahim Kara, 2018)Objective: Semen parameters are directly correlated with the infertility of the male. Incidence rates of male factor infertility, azoospermia and cryptozoospermia differ according to many factors such as geographic region, ... -
Mesenchymal stem cell applications in polycystic ovary syndrome treatment
Bülbül, Muhammet Volkan; Yıldırım, Berna; Kolbaşı, Bircan; Keskin, İlknur (Ondokuz Mayıs Üniversitesi, 2021)Mesenchymal stem cells (MSCs) are highly capable of self-renewal and differentiation. They can be isolated from a variety of sources such as adipose tissue, bone marrow, umbilical cord, tooth pulp and can be cultured under ... -
A novel approach in the treatment of osteoarthritis: In vitro and in vivo evaluation of Allium sativum microemulsion
Okur, Mehmet Evren; Kolbaşı, Bircan; Şahin, Mustafa; Karadağ, Ayşe Esra; Reis, Rengin; Çağlar, Emre Şefik; Kaplan, Arife Ahsen; Sipahi, Hande; Keskin, İlknur; Demiralp, Bahtiyar; Üstündağ Okur, Neslihan (Wiley, 2022)Osteoarthritis (OA) is the most prevalent kind of joint disease, affecting millions of individuals worldwide. Allium sativum L. was used as a therapeutic agent in the microemulsion system against osteoarthritis due to ... -
Possible relationship between bilateral elastofibroma dorsi and hypermastia
Elastofibroma dorsi (EFD) is a rare, benign, soft tissue tumor with an unclear pathogenesis, typically localized to the subscapular region. It occurs within the periscapular area between the ribs and dorsal chest wall ... -
Preclinical evaluation of scorzonera sp root extracts and major compounds against acute hepatotoxicity induced by carbon tetrachloride
Özbek, Hanefi; Bahadır Acıkara, Özlem; Keskin, İlknur; Kırmızı, Neriman İpek; Yiğitbaşı, Türkan; Sakul, Ayşe Arzu; İşcan, Gülçin Saltan (Wolters Kluwer Medknow Publications, 2017)Evaluation of hepatoprotective activities of Scorzonera roots and their major compounds, was aimed in current study. Scorzonera latifolia, S. tomentosa, S. mollis ssp. szowitsii, S. parviflora and S. cana var. jacquiniana ... -
Quercetin enhances human sperm motility in a dose and time dependent manner
Karabulut, Seda; Korkmaz, Oya; Erdem Altun, Ceren; Demiroğlu Zergeroǧlu, Asuman; Keskin, İlknur (Istanbul Medipol University, 2020)The aim of this study was to investigate the effect of quercetin on the motility of ejaculated human spermatozoa in asthenozoospermic cases by using different doses and exposure times. Semen samples of 94 men were incubated ... -
Role of erythropoietin and its receptor in the development of endometriosis in rats
Günal, Mehmet Yalçın; Ozansoy, Mehmet; Kılıç, Ülkan; Keskin, İlknur; Özdemir, Ekrem Musa; Aslan, İsmail; Eren, Zehra; Ersavaş, Cenk; Kılıç, Ertuğrul (Galenos Yayıncılık, 2019)Objective: Besides its hematopoietic function, erythropoietin (EPO) may protect tissues from degenerative disorders. As such, EPO and its receptors were revealed in nonhematopoietic cells, including stromal and endometrial ... -
The role of TNF-α and its target HSP-70 in triggering apoptosis in normozoospermic and non-normozoospermic samples
Karabulut, Seda; Gürsoy Gürgen, Duygu; Kutlu, Pelin; Keskin, İlknur (NLM (Medline), 2022)Objective: Semen analysis is performed as one of the screening tests for infertility, including motility, morphology, and concentration observation. We aimed to investigate the expression rates of tumor necrosis factor-α ... -
Seminal oxidation-reduction potential as a possible indicator of impaired sperm parameters in Turkish population
Karabulut, Seda; Korkmaz, Oya; Yılmaz, Elif; Keskin, İlknur (Wiley, 2021)Oxidative stress (OS) has been shown to have a key role in male infertility. Recently, a new measurement method has been developed to measure the overall oxidation-reduction potential (ORP) in a semen sample known as the ... -
Seminal trace elements and their relationship with sperm parameters
Karabulut, Seda; Korkmaz, Serol; Güneş, Ertuğrul; Kabil, Erol; Keskin, İlknur; Usta, Melek; Omurtag, Gülden Zehra (Wiley, 2022)Male reproductive problems may derive from many reasons including the environmental toxicants which may either intaken by occupational exposure, nutrition or bad air quality. The increased exposure to these substances due ... -
Sperm selection with Annexin-V coated polystrene bead technique (APB-Tech): A novel and reliable method for the microscopic selection of viable and non-apoptotic sperm to be used for intracytoplasmic sperm injection
Karabulut, Seda; Yalım Camcı, İrem; Atambay, Can; Yiğit, Pakize; Keskin, İlknur (Elsevier Inc., 2022)Infertility is a growing health problem that affects 20% of couples who want to conceive. ‘Intracytoplasmic sperm injection’ (ICSI) is a commonly used assisted reproduction treatment technique that offers the couples to ...