Yazar "Şensoy, Özge" için listeleme
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Perturb-Scan-Pull: A novel method facilitating conformational transitions in proteins
Jalalypour, Farzaneh; Şensoy, Özge; Atılgan, Canan (American Chemical Society, 2020)Conformational transitions in proteins facilitate precise physiological functions. Therefor; it is crucial to understand the mechanisms underlying these processes to modulate protein function. Yet, studying structural and ... -
Perturbation-response scanning reveals key residues for allosteric control in Hsp70
Penkler, David; Şensoy, Özge; Atılgan, Canan; Taştan Bishop, Özlem (American Chemical Society, 2017)Hsp70 molecular chaperones play-an important role in maintaining-cellular homeostasis, and are implicated in a wide array of cellular processes, including protein recovery from aggregates, cross-membrane protein translocation, ... -
Prediction and targeting of interaction interfaces in g-rotein coupled receptor oligomers
Schiedel, Anke C.; Köse, Meryem; Barreto, Carlos; Bueschbell, Beatriz; Morra, Giulia; Şensoy, Özge; Moreira, Irina Sousa (Bentham Science Publishers Ltd, 2018)Background: Communication within a protein complex is mediated by physical interactions made among the protomers. Evidence for both the allosteric regulation present among the protomers of the protein oligomer and of the ... -
The single nucleotide beta-arrestin2 variant, A248T, resembles dynamical properties of activated arrestin
Şensoy, Özge (TUBITAK Scientific & Technical Research Council Turkey, 2020)beta-arrestins are responsible for termination of G protein-coupled receptor (GPCR)-mediated signaling. Association of single nucleotide variants with onset of crucial diseases has made this protein family hot targets in ... -
Synthesis, structural investigations, DNA/BSA interactions, molecular docking studies, and anticancer activity of a new 1,4-disubstituted 1,2,3-triazole derivative
Göktürk, Tolga; Sakallı Çetin, Esin; Hökelek, Tuncer; Pekel, Hanife; Şensoy, Özge; Aksu, Ebru Nur; Güp, Ramazan (American Chemical Society, 2023)We report herein a new 1,2,3-triazole derivative, namely, 4-(( 1-( 3,4-dichlorophenyl)-1H-1,2,3- triazol- 4-yl)methoxy)-2-hydroxybenzaldehyde, which was synthesized by copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). ... -
Understanding the differential selectivity of arrestins toward the phosphorylation state of the receptor
Şensoy, Özge; Moreira, Irina Sousa; Morra, Giulia (American Chemical Society, 2016)Proteins in the arrestin family exhibit a conserved structural fold that nevertheless allows for significant differences in their selectivity for G-protein coupled receptors (GPCRs) and their phosphorylation states. To ... -
Utilization of biased G protein-coupled receptor signaling towards development of safer and personalized therapeutics
İlter, Metehan; Mansoor, Samman; Şensoy, Özge (MDPI, 2019)G protein-coupled receptors (GPCRs) are involved in a wide variety of physiological processes. Therefore, approximately 40% of currently prescribed drugs have targeted this receptor family. Discovery of beta-arrestin ...